Clinical Evidence for TruScient®

The use of TruScient® is supported by evidence from a randomised, controlled, multi-centre trial in 133 dogs.

Study design and population

The study included dogs with acute diaphyseal fracture of a long bone (femur, humerus, radius, radius + ulna, ulna, tibia, tibia + fibula).

Intervention consisted of either surgical standard of care (SOC) alone or TruScient® in combination with SOC.

TruScient® study design and baseline characteristics

SOC TruScient® + SOC
Intervention Anaesthesia, perioperative pain management and fracture reduction / stabilisation as determined by vetinary surgeon TruScient® (rhBMP-2, 0.2 mg/mL in <2 sponges) implanted at fracture site and surgical protocol as in SOC group
N 46 87
Mean age (years) 3.0 (range 0.6-13.0) 3.8 (range 0.7-13.0)
Mean body weight (kg) 17.1 (range 2.0-52.2) 18.8 (range 1.7-70.9)
Primary Endpoint Time to radiographic fracture union ?

Radiographic fracture healing

Adverse Events